#I doser doses torrents torrent#

#I doser doses torrents torrent#

Lercanidipine HCl Torrent is known to be metabolized by the CYP3A4 enzyme and, therefore, inhibitors and inducers of CYP3A4 administered concurrently may interact with the metabolism and elimination of Lercanidipine HCl Torrent.Ĭo-prescription of Lercanidipine HCl Torrent with inhibitors of CYP3A4 (eg, ketoconazole, itraconazole, ritonavir, erythromycin, troleandomycin) should be avoided.Īn interaction study with a strong CYP3A4 inhibitor, ketoconazole, has shown a considerable increase in plasma levels of Lercanidipine HCl Torrent (a 15-fold increase of the AUC and an 8-fold increase in the C max for the eutomer S-Lercanidipine HCl Torrent).Ĭyclosporine and Lercanidipine HCl Torrent should not be administered together. Lercanidipine HCl Torrent is not recommended for use in patients with severe hepatic impairment or in patients with severe renal impairment (GFR <30 mL/min). The antihypertensive effect may be enhanced in patients with hepatic impairment and consequently an adjustment of the dosage should be considered.

Although the usual recommended dose schedule may be tolerated by these subgroups, an increase in dose to 20 mg daily must be approached with caution. Renal or Hepatic Impairment: Special care should be exercised when treatment is commenced in patients with mild to moderate renal or hepatic dysfunction. Since the dose-response curve is steep with a plateau at doses between 20-30 mg, it is unlikely that efficacy will be improved by higher doses whereas side effects may increase.Įlderly: Although the pharmacokinetic data and clinical experience suggest that no adjustment of the daily dosage is required, special care should be exercised when initiating treatment in the elderly. Some individuals, not adequately controlled on a single antihypertensive agent, may benefit from the addition of Lercanidipine HCl Torrent to therapy with a β-adrenoceptor blocking drug (atenolol), a diuretic (hydrochlorothiazide) or an angiotensin-converting enzyme (ACE) inhibitor (captopril or enalapril). In severe hypertension, the dose titration period should be reduced.

The dose may be increased to 20 mg depending on the individual patient's response.ĭose titration should be gradual because it may take about 2 weeks before the maximal antihypertensive effect is apparent. Recommended Dose: 10 mg orally once daily at least 15 min before meals.